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Regulation of ceramide-induced neuronal death: Cell metabolism meets neurodegeneration

✍ Scribed by Gonzalo Arboleda; Luis Carlos Morales; Bruno Benítez; Humberto Arboleda

Book ID
113506364
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
853 KB
Volume
59
Category
Article
ISSN
0165-0173

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Ceramide is a sphingolipid that has been implicated both in apoptosis and protection from cell death. We show that in both rat cerebellar granule cells and cortical neuronal cultures application of C(2)-ceramide causes cell death in a dose- and time-dependent manner. Similar effects were observed wi