Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death
β Scribed by Arundhati Jana; Edward L. Hogan; Kalipada Pahan
- Book ID
- 119302929
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 524 KB
- Volume
- 278
- Category
- Article
- ISSN
- 0022-510X
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Ceramide has been shown to induce apoptosis in leukaemic cells and some other cell types, but there are few data on its role in neuronal cells. We investigated the effect of ceramide and its analogues in cultured sensory neurons from neonatal mice. These cells undergo apoptosis in the absence of neu
Ceramide is a lipid second messenger implicated in the mechanism of apoptotic cell death. The effect of the cell-permeable ceramide analogue C2 has been tested on primary cortical cultures of neurons, astrocytes, and oligodendrocytes as well as on the bipotential glial precursor cell line CG-4. Afte