Regulation of cancer germline antigen gene expression: implications for cancer immunotherapy
β Scribed by Akers, Stacey N; Odunsi, Kunle; Karpf, Adam R
- Book ID
- 126670196
- Publisher
- Future Medicine
- Year
- 2010
- Tongue
- English
- Weight
- 876 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1479-6694
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## Abstract Cancer/germline (CG) antigens represent promising targets for widely applicable monoβ and multiantigen cancer vaccines for nonsmall cell lung cancer (NSCLC). Since little is known about their composite expression in this tumor type, we analyzed 7 CG genes (__MAGEβA3__, __NYβESOβ1__, __L
## Abstract Some human tumors express known antigens that can be utilized as targets for specific immunotherapy. An absolute requirement for the efficacy of this therapeutic strategy is an adequate expression of the candidate antigen by all cells of the primary and metastatic tumor. To examine the