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Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer

✍ Scribed by Carolin Grunwald; Michael Koslowski; Tülin Arsiray; Karl Dhaene; Marleen Praet; Anja Victor; Alicia Morresi-Hauf; Michael Lindner; Bernward Passlick; Hans-Anton Lehr; Stephan C. Schäfer; Gerhard Seitz; Christoph Huber; Ugur Sahin; Özlem Türeci

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
237 KB
Volume
118
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Cancer/germline (CG) antigens represent promising targets for widely applicable mono‐ and multiantigen cancer vaccines for nonsmall cell lung cancer (NSCLC). Since little is known about their composite expression in this tumor type, we analyzed 7 CG genes (MAGE‐A3, NY‐ESO‐1, LAGE‐1, BRDT, HOM‐TES‐85, TPX‐1 and LDHC) in 102 human NSCLC specimens. About 81% of NSCLC express at least 1 and half of the specimen at least 2 CG genes. Activation of most of these genes occurs more frequently in squamous cell cancer than in adenocarcinomas. Even though we found all genes but one to be regulated by genomic methylation, not all of them are co‐expressed. In particular, combining CG genes not localized on the X‐chromosome may provide effective treatment for an extended number of patients. © 2005 Wiley‐Liss, Inc.

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