Regulation of BRCA1 by protein degradation
β Scribed by Blagosklonny, Mikhail V; An, Won G; Melillo, Giovanni; Nguyen, Phuongmai; Trepel, Jane B; Neckers, Leonard M
- Book ID
- 110062445
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 606 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0950-9232
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## Abstract BRCA1 is a tumor suppressor gene that is mutated in families with breast and ovarian cancer. Several BRCA1 splice variants are found in different tissues, but their subcellular localization and functions are poorly understood at the moment. We previously described BRCA1 splice variant B
## Abstract The subcellular location and function of many proteins are regulated by nuclearβcytoplasmic shuttling. BRCA1 and BARD1 provide an interesting model system for understanding the influence of protein dimerization on nuclear transport and localization. These proteins function predominantly