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Negative Regulation of BRCA1 Gene Expression by HMGA1 Proteins Accounts for the Reduced BRCA1 Protein Levels in Sporadic Breast Carcinoma

✍ Scribed by Baldassarre, G.; Battista, S.; Belletti, B.; Thakur, S.; Pentimalli, F.; Trapasso, F.; Fedele, M.; Pierantoni, G.; Croce, C. M.; Fusco, A.

Book ID
118065679
Publisher
American Society for Microbiology
Year
2003
Tongue
English
Weight
739 KB
Volume
23
Category
Article
ISSN
0270-7306

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## Abstract The LIM domain‐only genes __LMO1__ and __LMO2__ are translocated in acute T cell leukemia (T‐ALL) and have been shown to be oncogenes in T lymphoid cells. LMO4, the fourth member of this family, is overexpressed in more than 50% of sporadic breast cancers, suggesting a role in breast on