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Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

✍ Scribed by Cyster, Jason G.; Healy, James I.; Kishihara, Kenji; Mak, Tak W.; Thomas, Matthew L.; Goodnow, Christopher C.

Book ID
109795967
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
927 KB
Volume
381
Category
Article
ISSN
0028-0836

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Positive and negative regulation of Src-
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D45 is the major transmembrane tyrosine phosphatase of the immune system and is highly expressed by all hematopoietic cells 1 . The best described role for CD45 is in antigen receptor signal transduction. In this case, the phosphatase activity of CD45 appears to be required for activation of Src-fam