๐”– Bobbio Scriptorium
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Regulation of B lymphocyte activation by the Fc portion of immunoglobulin

โœ Scribed by Morgan, Edward L. ;Weigle, William O.

Publisher
Wiley (John Wiley & Sons)
Year
1980
Tongue
English
Weight
439 KB
Volume
14
Category
Article
ISSN
0091-7419

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โœฆ Synopsis

Abstract

Murine splenic B lymphocytes are induced to proliferate and undergo polyclonal activation in the presence of Fc fragments, AHGG, antigenโ€antibody complexes, and CH~3~ fragments derived from plasmin digestion of human Ig. The unifying feature of the polyclonal antibody response induced by these agents is that in all cases a portion of the constant region of the Ig molecule (ie, Fc region) is present. Fragments of Ig lacking the Fc piece, such as Fab and F(abโ€ฒ)~2~ were found not to be stimulatory. In addition, a model is proposed to account for the regulatory effects of antigenโ€antibody complexes on an ongoing humoral immune response.

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