𝔖 Bobbio Scriptorium
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Activation of T lymphocytes by the Fc portion of immunoglobulin

✍ Scribed by Thoman, Marilyn L. ;Morgan, Edward L. ;Weigle, William O.

Publisher
Wiley (John Wiley & Sons)
Year
1980
Tongue
English
Weight
562 KB
Volume
13
Category
Article
ISSN
0091-7419

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✦ Synopsis

Abstract

T lymphocytes are stimulated to release T‐cell‐replacing factors in response to Fc fragments of human IgG. Lyt 1^+^23^−^ T cells are directly triggered to factor production by Fc subfragments, derived from intact Fc fragments by macrophage‐dependent enzymatic cleavage. These factor(s) replace T cell function in two Fc‐mediated immune responses; induction of polyclonal antibody synthesis, and potentiation of anti‐SRBC responses.

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