𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Regulation of B cell growth and differentiation via CD21 and CD40

✍ Scribed by Karol Axcrona; David Gray; Tomas Leanderson

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
465 KB
Volume
26
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Stimulation in vitro of murine splenic B cells by lipopolysaccharide, anti-x Sepharose, anti-CD40 or allo-reactive T helper cells all up-regulated CD21 and CD23 surface expression. Neither anti-CD21 nor anti-CD23 antibodies induced B cell growth or differentiation when added in soluble form or coupled to Sepharose. However, anti-CD40-stimulated B cells showed increased proliferation in the presence of anti-CD21 antibodies coupled to Sepharose; co-stimulation via CD21 also induced differentiation to immunoglobulin secretion in a fraction of anti-CD40-stimulated B cells. Furthermore, antLCD40 antibodies inhibited differentiation to immunoglobulin secretion induced by lipopolysaccharide and, hence, appears to be a dominant negative signal for B cell differentiation.

πŸ“œ SIMILAR VOLUMES

Down-regulation of CD20 on B cells upon
Down-regulation of CD20 on B cells upon CD40 activation
✍ Jennifer Anolik; R. John Looney; Andrea Bottaro; IΓ±aki Sanz; Fay Young πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 566 KB

## Abstract CD20 is a B cell‐specific surface antigen that is thought to play an important role in B cell activation and proliferation, possibly by functioning as a calcium channel or interacting with other cell surface molecules important in B cell signal transduction, such as CD40. In this study,

HUMAN B CELL DIFFERENTIATION: DEPENDENCE
HUMAN B CELL DIFFERENTIATION: DEPENDENCE ON INTERACTIONS WITH MONOCYTES AND T LYMPHOCYTES VIA CD40, CD80 (B7.1), AND THE CD2-LIGANDS CD48 AND CD58 (LFA-3)
✍ JΓ–RG C HOFFMANN; HARTMUT KRÜGER; STEFAN ZIELEN; BETTINA BAYER; HENNING ZEIDLER πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 English βš– 243 KB

B cell differentiation depends on cellular interactions with T lymphocytes and monocytes via adhesion molecules (AM). In order to characterize AM which are required for B cell differentiation immunoglobulin production using unseparated peripheral blood mononuclear cells (PBMC) was studied. Unstimula