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REGULATION OF APO-2 LIGAND/TRAIL EXPRESSION IN NK CELLS—INVOLVEMENT IN NK CELL-MEDIATED CYTOTOXICITY

✍ Scribed by Ann-Charlotte Johnsen; Johan Haux; Bjørg Steinkjer; Unni Nonstad; Kjartan Egeberg; Anders Sundan; Avi Ashkenazi; Terje Espevik


Book ID
115596336
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
271 KB
Volume
11
Category
Article
ISSN
1043-4666

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The activation of protein tyrosine kinase(s) (PTK) is a critical event required for the development of NK cell-mediated cytotoxicity. Here we demonstrate that the adaptor protein shc undergoes tyrosine phosphorylation during the generation of antibody-dependent cellular cytotoxicity (ADCC) and natur