Homeostatic regulation of CD8+ T cells b
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David KΓ€gi; Bernhard Odermatt; Tak W. Mak
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Article
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1999
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John Wiley and Sons
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English
β 273 KB
To prevent uncontrolled expansion, the massive proliferation of T cells during an acute immune response has to be followed by controlled deletion. Here we show that similar to Fas, perforin is not only an important effector molecule of cytotoxic T lymphocytes (CTL) but also involved in down-regulati