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Regulating the licensing of DNA replication origins in metazoa

✍ Scribed by Melvin L DePamphilis; J Julian Blow; Soma Ghosh; Tapas Saha; Kohji Noguchi; Alex Vassilev

Book ID
113524786
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
389 KB
Volume
18
Category
Article
ISSN
0955-0674

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## Abstract To prevent duplicate DNA synthesis, metazoan replication origins are licensed during G1. Only licensed origins can initiate replication, and the cytoplasm interacts with the nucleus to inhibit new licensing during S phase. DNA replication in the mammalian one‐cell embryo is unique becau

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