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Regulating Enzymatic Activity with a Photoswitchable Affinity Label

✍ Scribed by Jessica H. Harvey; Dirk Trauner


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
248 KB
Volume
9
Category
Article
ISSN
1439-4227

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Cover Picture: Regulating Enzymatic Acti
✍ Jessica H. Harvey; Dirk Trauner πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 664 KB

The cover picture shows a photoswitchable affinity label (PAL) in its trans form bound noncovalently to bovine carbonic anhydrase 2. Potential reactive nucleophiles surrounding the PAL are highlighted in yellow. Histidines 2 and 3, which eventually undergo the bioconjugation, are shown in red. After