✦ LIBER ✦

Cover Picture: Regulating Enzymatic Activity with a Photoswitchable Affinity Label (ChemBioChem 2/2008)

✍ Scribed by Jessica H. Harvey; Dirk Trauner

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 664 KB
Volume: 9
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.200890000

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✦ Synopsis

The cover picture shows a photoswitchable affinity label (PAL) in its trans form bound noncovalently to bovine carbonic anhydrase 2. Potential reactive nucleophiles surrounding the PAL are highlighted in yellow. Histidines 2 and 3, which eventually undergo the bioconjugation, are shown in red. After bioconjugation, the affinity label can be withdrawn from the active site through photoisomerization (upper left corner). For details see the article by J. H. Harvey and D. Trauner on p. 191 ff.

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