Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis

✍ Scribed by Ilias G. Kirkinezos; Dayami Hernandez; Walter G. Bradley; Carlos T. Moraes

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 138 KB
• Volume: 53
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.10597

✦ Synopsis

Abstract

We tested whether a regular exercise regimen was associated with a change in the life span of G93A‐SOD1 transgenic mice, a model of familial ALS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A‐SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A‐SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS. Ann Neurol 2003;53:804–807