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Regiospecific total synthesis of juncusol

โœ Scribed by Boger, Dale L.; Mullican, Michael D.


Book ID
126923678
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
824 KB
Volume
49
Category
Article
ISSN
0022-3263

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๐Ÿ“œ SIMILAR VOLUMES


Regiospecific total synthesis of juncuso
โœ Dale L. Boger; Michael D. Mullican ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 213 KB

A regiospecific total synthesis of juncusol (1) based on the use of two consecutive phenol annulations is detailed. A recent search for the antileukemic constituents in the extracts of needle rush, Juncus ~ roemerianus, resulted in the isolation and identification of juncusol (l\_), a highly substit

Total synthesis of juncusol
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Total synthesis of juncusol
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A recent communication by Miles et al. has described the structure of juncusol (11, a constituent of the extracts of the needlerush (Juncus roemerianus).' In view of the confirmed cytotoxic activity (ED50 = 0.3 ug/ml) of juncusol against the NC1 90 KEI human epidermoid carci-

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The pioneering work of Wong et al in 1971-73' was the first of a growing series of investigations toward the efficient laboratory synthesis of clinically useful anthracycline antibiotics. Although several total syntheses of (\*)-daunomycinone (IIIa) and adriamycinone (IIIb) have been reported,' only