A novel synthesis of juncusol
โ Scribed by Peter A. Jacobi; Wanjun Zheng
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 249 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Juncusol (7) has been prepared by a novel electrocyclization process beginning with the known &tetralone derivative 9.
๐ SIMILAR VOLUMES
A recent communication by Miles et al. has described the structure of juncusol (11, a constituent of the extracts of the needlerush (Juncus roemerianus).' In view of the confirmed cytotoxic activity (ED50 = 0.3 ug/ml) of juncusol against the NC1 90 KEI human epidermoid carci-
A regiospecific total synthesis of juncusol (1) based on the use of two consecutive phenol annulations is detailed. A recent search for the antileukemic constituents in the extracts of needle rush, Juncus ~ roemerianus, resulted in the isolation and identification of juncusol (l\_), a highly substit