Regiospecific synthesis of α-methylene-ketals and-ketones
✍ Scribed by F. Huet; M. Pellet; J.M. Conia
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- French
- Weight
- 153 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Synthetic routes to a(-methylene carbonyl compounds C_ have received considerable attention (1 -4). Most of them involve either a p-elimination from Mannich
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lsomeric en01 ester, enamine, and silyl enol ether derivatives of unsymmetrical ketones are converted regiospecifically to d-arylsulfonoxy ketones with arylsulfonyl peroxides.
AbstractÐA convenient synthesis of a-diones and their monoprotected acetals, i.e. a-ketoacetals, was developed by mercury induced solvolysis of regiospeci®cally formed a-chloro-a-(alkylthio)ketones. Analogously, a-alkoxy-a-sulfenylated ketones were formed when reacting a-chloro-a-sulfenylated ketone