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Regiospecific synthesis of 2-allyl-1,2,3-triazoles by palladium-catalyzed 1,3-dipolar cycloaddition

✍ Scribed by Shin Kamijo; Tienan Jin; Zhibao Huo; Yoshinori Yamamoto

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
129 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

2-Allyl-1,2,3-triazoles were prepared by the palladium-catalyzed three component coupling (TCC) reaction of alkynes, allyl methyl carbonate and trimethylsilyl azide. A p-allylpalladium azide complex, which undergoes the 1,3-dipolar cycloaddition with alkynes, is proposed as a key intermediate in the TCC reaction.

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## Abstract We report the total synthesis of a triazole‐epothilone analogue **1**. The key step to generate the macrocyclic ring and the triazole ring was to apply Cu~2~O nanoparticles (Cu~2~O‐NPs) to catalyze the 1,3‐dipolar cycloaddition. The conformation of **1** and its bioactivity in MCF cance