Synthesis of Triazole-Epothilones by Using Cu2O Nanoparticles to Catalyze 1,3-Dipolar Cycloaddition

✍ Scribed by Xiyan Duan; Yan Zhang; Yahui Ding; Jianping Lin; Xianglei Kong; Quan Zhang; Changming Dong; Guoan Luo; Yue Chen

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 936 KB
• Volume: 2012
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.201101306

✦ Synopsis

Abstract

We report the total synthesis of a triazole‐epothilone analogue 1. The key step to generate the macrocyclic ring and the triazole ring was to apply Cu~2~O nanoparticles (Cu~2~O‐NPs) to catalyze the 1,3‐dipolar cycloaddition. The conformation of 1 and its bioactivity in MCF cancer cell lines were investigated.