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Regiospecific and diastereoselective aldol reaction of chiral N-sulfinyl metalloenamines with α,β-unsaturated trifluoromethyl ketones: Asymmetric synthesis of tertiary trifluoromethyl allylic carbinols

✍ Scribed by Zhen-Jiang Liu; Fan Zhang; Jin-Tao Liu

Book ID
113711572
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
368 KB
Volume
133
Category
Article
ISSN
0022-1139

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✍ Fan Zhang; Zhenjiang Liu; Jintao Liu 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB

## Abstract The reaction of chiral __N__‐(__tert__‐butanesulfinyl)ketimines and __α__,__β__‐unsaturated trifluoromethyl ketones catalyzed by DBU was achieved under mild conditions. 1,2‐Addition products, precursors of chiral trifluoromethylated 1,3‐amino alcohols, were obtained diastereoselectively