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Regioselectivity of enamine reactions, preferential 2,2-disubstitution of 2-methylcyclohexanone imines

✍ Scribed by Peter W. Hickmott; Bruce Rae

Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
215 KB
Volume
26
Category
Article
ISSN
0040-4039

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✦ Synopsis

Secondary enamines, derived from imines of unsyrunetrical a-substituted ketones, react with electrophilic alkenes at the more substituted position to give a,cr-disubstituted ketones on hydrolysis.

Spectroscopic studies"' of imine-enamine tautomerism have shown that, unless the

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