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ChemInform Abstract: Regioselective Nucleophilic Ring Opening Reactions of 2,2- Disubstituted Aziridines - The Asymmetric Synthesis of α,α- Disubstituted Amino Acids.

✍ Scribed by B. G. M. BURGAUD; D. C. HORWELL; A. PADOVA; M. C. PRITCHARD

Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Regioselective Nucleophilic Ring Opening Reactions of 2,2-Disubstituted Aziridines -The Asymmetric Synthesis of α,α-Disubstituted Amino Acids.

-It is shown that, under appropriate conditions, 2,2disubstituted aziridines like (I) and (V) undergo regioselective ring opening reactions at C-3 with carbon, nitrogen, and sulfur nucleophiles to afford desired α,α-disubstituted amino acid derivatives. This method should be generally applicable and is complementary to existing approaches. -(BURGAUD, B.

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