Regioselective synthesis of a-ring halogenated derivatives of 17α-ethynyloestradiol
✍ Scribed by Philip C. Bulman Page; Fazal Hussain; Nicholas M. Bonham; Paul Morgan; James L. Maggs; B.Kevin Park
- Book ID
- 108371673
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 550 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
Sumnary -Depending upon the reaction conditions, norethisterone (1) and its ketal 2 can be transformed with tributyltin hydride to either the (E)-or (Z)-17a-(2-tributylstannylvinyl)-nortestosterone derivatives 3, 8 and 13. Further treatment with N-bromo-or N-iodosuccinimide yields the corresponding
Series of ring-halogenated histidines and histamines have been synthesized horn the suitably protected parent bioimidazoles. The 5-X and 2,5-X\*-derivatives are obtained by dii electrophilic halogenation while 2-X derivatives (X= Br and I) are prepared by rcgiospecific electrophilic dehalogenation a
## Abstract The stereoselective synthesis of a 2‐substituted tetrahydropyran with adjacent alkoxy‐bearing stereogenic centre is described. The key steps of this synthesis were the stereoselective epoxidation of an allylic alcohol and the regioselective epoxide ring opening by lithium aluminum hydri