N-Ethoxycarbonylpyridinium chloride (A) reacted with RCu. BF3 at 4position with almost complete regioselectivity ( better than 99% ) to afford the corre-
Regioselective Synthesis of 4-Alkylpyridines from Pyridine and Aldehydes via Dipole Reversal Process of 1,4-Dihydropyridine Phosphonate.
โ Scribed by Phil Ho Lee; Kooyeon Lee; Jun Hwan Shim; Seong Guk Lee; Sundae Kim
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 20 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
Trimethylsilyl enol ethers ( 1 ) reacted with l-ethoxycarbonylpyridinium chloride (2 ) at 4-position with high rezoselectivity to afford l-ethoxycarbonyl-4-( 2-oxoalkyl )-1,4\_dihydropyridines ( 2 ) in 42 -8'7% yields. When 2, 2, 2-trichloroethyl chloroformate was employed, yields of the correspond
An efficient synthetic method of poly-substituted pyridines was developed. Various poly-substituted pyridines were prepared from the combination of Baylis-Hillman adducts (3 carbons), activated methylene compounds (2 carbons) and ammonium acetate (1 nitrogen) via [3+2+1] annulation protocol in good
## Abstract Novel 4,7โdihydrothieno[2,3โ__b__]pyridines 10aโd have been prepared in a one step procedure from the readily available __o__โchloroformyl substituted 1,4โdihydropyridines 9aโd and ethyl mercaptoacetate in good yields. Semiempirical calculations reveal a favoured geometry with a boat co