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Regioselective synthesis of 1,2,4,5-tetrasubstituted pyridines from Baylis–Hillman adducts via consecutive [3+2+1] annulation protocol

✍ Scribed by Sung Hwan Kim; Ko Hoon Kim; Hoo Sook Kim; Jae Nyoung Kim

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
118 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient synthetic method of poly-substituted pyridines was developed. Various poly-substituted pyridines were prepared from the combination of Baylis-Hillman adducts (3 carbons), activated methylene compounds (2 carbons) and ammonium acetate (1 nitrogen) via [3+2+1] annulation protocol in good yields, regioselectively.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.