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Regioselective Synthesis of 3-Alkynyl-5-bromo-2-pyrones via Pd-Catalyzed Couplings on 3,5-Dibromo-2-pyrone

✍ Scribed by Lee, Jin-Hee; Park, Jung-Sang; Cho, Cheon-Gyu


Book ID
111923154
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
48 KB
Volume
4
Category
Article
ISSN
1523-7060

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An efficient synthesis of 4-alkenyl/alky
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We herein report the efficient syntheses of biologically active 4-alkenyl-and 4-alkynyl-6-methyl-2-pyrones using Pd-catalysed coupling procedures. A palladium on carbon/triphenylphosphine combination is shown to be the most effective catalyst for Sonogashira cross-coupling of several terminal acetyl