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An efficient synthesis of 4-alkenyl/alkynyl-6-methyl-2-pyrones via Pd-catalysed coupling on 4-bromo-6-methyl-2-pyrone

✍ Scribed by Lester R. Marrison; Julia M. Dickinson; Razwan Ahmed; Ian J.S. Fairlamb

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 137 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02207-4

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✦ Synopsis

We herein report the efficient syntheses of biologically active 4-alkenyl-and 4-alkynyl-6-methyl-2-pyrones using Pd-catalysed coupling procedures. A palladium on carbon/triphenylphosphine combination is shown to be the most effective catalyst for Sonogashira cross-coupling of several terminal acetylenes with 4-bromo-6-methyl-2-pyrone in yields of up to 95%.

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