Regioselective Synthesis of 2 H -Indazoles Using a Mild, One-Pot Condensation–Cadogan Reductive Cyclization
✍ Scribed by Genung, Nathan E.; Wei, Liuqing; Aspnes, Gary E.
- Book ID
- 124050814
- Publisher
- American Chemical Society
- Year
- 2014
- Tongue
- English
- Weight
- 485 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1523-7060
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## Abstract magnified image Ruthenium trichloride was found to be an efficient catalyst for the first time for the synthesis of a variety of 3,4‐dihydropyrimidin‐2(1__H__)‐ones by cyclocondensation of an aldehyde, β‐dicarbonyl compound and urea in excellent yields under mild reaction conditions.
## Abstract Coupling of active [(4‐oxo‐6‐phenyl‐3__H__‐pyrimidin‐2‐yl)thio]methine compounds (**3**) with diazotized anilines in the presence of base gave [1,2,4]triazolo[4,3‐a]pyrimidines (**7**). The latter products were also obtained by reactions of hydrazonoyl chlorides (**10**) with either 6‐p