Regioselective Suzuki–Miyaura reactions of the bis(triflate) of 1,2,3,4-tetrahydro-9,10-dihydroxyanthracen-1-one

✍ Scribed by Ghazwan A. Salman; Ahmed Mahal; Mohanad Shkoor; Munawar Hussain; Alexander Villinger; Peter Langer

• Book ID: 104098611
• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 513 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.11.052

✦ Synopsis

The palladium(0)-catalyzed Suzuki cross-coupling reaction of the bis(triflate) of 1,2,3,4-tetrahydro-9,10dihydroxyanthracen-1-one afforded various aryl-substituted 1,2,3,4-tetrahydroanthracen-1-ones. The reactions proceeded with very good site-selectivity in favour of position 10, due to electronic reasons.