The regioselectivity of nucleophilic ring opening of some 3,4-epoxy and 3,4-aziridino alcohols has been studied. The nucleophiles chosen were complex hydrides (LiAIH4, Red-Al and DIBAL) and Lipshutz-or Gilman-type organocuprate reagents. The C-4 substituent in the substrates was varied in order to s
Regioselective Ring-Opening Nucleophilic Addition of Aziridines through Photoredox Catalyst
β Scribed by Sun, Hongnan; Yang, Chao; Lin, Run; Xia, Wujiong
- Book ID
- 127392722
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 344 KB
- Volume
- 356
- Category
- Article
- ISSN
- 1615-4150
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Regioselective Nucleophilic Ring Opening of Epoxides and Aziridines Derived from Homoallylic Alcohols. -The title investigation is carried out with a view to providing a method for the regioselective preparation of 1,4diols or amino alcohols as building blocks for the synthesis of natural products.
Regioselective Nucleophilic Ring Opening Reactions of 2,2-Disubstituted Aziridines -The Asymmetric Synthesis of Ξ±,Ξ±-Disubstituted Amino Acids. -It is shown that, under appropriate conditions, 2,2disubstituted aziridines like (I) and (V) undergo regioselective ring opening reactions at C-3 with carb