Lithium borohydride reduction of 2,3-epoxy alcohols was shown to yield 1,2-diols in high regioselectivity with the aid of titanium tetraisopropoxide in benzene solution.
β¦ LIBER β¦
Regioselective reductions of 2,3-epoxy alcohols
β Scribed by Steven M. Viti
- Book ID
- 104219657
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 178 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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Lithium organocuprates react with 3-alkyl-2,3-epoxy acids (glycidic acids) to afford the products of ring-opening in good yield. The regiochemistry of ringopening is dependent on the stereochemistry of the epoxy acid.