Regioselective Metalation of Fluoroanilines. An Application to the Synthesis of Fluorinated Oxazolidinone Antibacterial Agents
β Scribed by Grega, Kevin C.; Barbachyn, Michael R.; Brickner, Steven J.; Mizsak, Stephen A.
- Book ID
- 127083093
- Publisher
- American Chemical Society
- Year
- 1995
- Tongue
- English
- Weight
- 1019 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
A method for the intermolecular coupling of aryl bromides and oxazolidinones is described. Application to intermediates useful for the preparation of a known class of antibacterial agent and the synthesis of the known antibacterial oxazolidinone Dup-721 are described.
Starting from fluoropyrazine, a general synthetic route including metallation and palladium-catalyzed cross-coupling reactions is described to access to rod-like alkylaryl or diarylpyrazines. Among them, some have liquid crystalline properties.