Regioselective hydroboration-oxidation and -amination of fluoro-substituted styrenes
✍ Scribed by P. Veeraraghavan Ramachandran; Sateesh Madhi; Martin J. O’Donnell
- Book ID
- 108170453
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 203 KB
- Volume
- 127
- Category
- Article
- ISSN
- 0022-1139
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Grignard reagents and dialkylmagnesium compounds react differently with many epoxides.
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## Abstract An improved synthetic approach to protopines based on the sequential Hofmann elimination, hydroboration and oxidation of __N__‐(arylmethyl)berbinium salts has been designed. By using berberine chloride as the starting material, this sequence of reactions has provided two new nonnatural