✦ LIBER ✦
From Berbines to Protopines: Regiocontrolled Hofmann Elimination/Hydroboration/Oxidation of N-Substituted Berbinium Salts
✍ Scribed by María Valpuesta; Amelia Díaz; Rafael Suau; Gregorio Torres
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 170 KB
- Volume
- 2006
- Category
- Article
- ISSN
- 1434-193X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
An improved synthetic approach to protopines based on the sequential Hofmann elimination, hydroboration and oxidation of N‐(arylmethyl)berbinium salts has been designed. By using berberine chloride as the starting material, this sequence of reactions has provided two new nonnatural protopines, N‐benzyl‐N‐nordihydroallocriptopine and N‐(p‐methoxybenzyl)‐N‐nordihydroallocriptopine and the natural allocriptopine. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)