Regioselective esterification of diols and triols with lipases in organic solvents
โ Scribed by V.S. Parmar; Rita Sinha; K.S. Bisht; Sandhya Gupta; A.K. Prasad; Poonam Taneja
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 782 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4020
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โฆ Synopsis
Lipases from porcine pancreas (PPL) and Candida cylindracea (CCL) in different organic solvents allow discrimination of the primary and secondary hydroxyl groups, and also between two primary hydroxyl groups towards acylation with 2,2,2-trifluoroethyl butyrate in diols and triols with high regioselectivity.
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For the esterification of 2-(4-ethylphenoxy)propionic acid catalyzed by lipase MY (Candida rugosa) in isopropyl ether containing a suitable amount of water, the enantioselectivity for the reaction has become higher asthe reaction temperature increasing. In contrast, the reverse trend of the tempera
Resolution of rac-flurbiprofen, 2-fluoro-0t-methyi-[1,1'-biphenyl]-4-scetic acid (1), by biocatalytic methodologies has been studied. Enzymatic hydrolysis of rac-flurbiprofen methyl ester (2) in aqueous-organic medium gave poor results. Transesterification of the same ester mediated by immobilized l