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Regioselective electrophilic trifluoromethylation of substituted anilines and derivatives in superacid

✍ Scribed by Sébastien Debarge; Bruno Violeau; Nohair Bendaoud; Marie-Paule Jouannetaud; Jean-Claude Jacquesy

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 223 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00124-2

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✦ Synopsis

In a one pot procedure, treatment of chloro or methyl substituted acetanilides in HF/SbF 5 /CCl 4 followed by addition of HF/pyridine yields trifluoromethyl derivatives with high regioselectivity.

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