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Regioselective directed lithiation of N-Boc 3-hydroxypyrrolidine. Synthesis of 2-substituted 4-hydroxypyrrolidines

✍ Scribed by Sunose, Mihiro; Peakman, Torren M.; Charmant, Jonathan P. H.; Gallagher, Timothy; Charmant, Jonathan P. H.; Macdonald, Simon J. F.

Book ID
111900287
Publisher
Royal Society of Chemistry
Year
1998
Tongue
English
Weight
57 KB
Volume
16
Category
Article
ISSN
1359-7345

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Lewis Acid-mediated coupling reactions of (5R, 6S)-2-acetoxy-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazine (2a) with aUylsilanes (3a-d) proceeded to give the coupling products (4a-b) with moderate to good stereoselectivity. The coupling products (4a-b) were effectively convert