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Synthesis of 4‐Substituted‐ and 1,4‐Disubstituted‐4‐Hydroxypyrrolidin‐2‐ones

✍ Scribed by Kinsinger, Christopher R.; Tatko, Chad D.; Whelan, Christopher M.; Wilkinson, Timothy J.


Book ID
121326979
Publisher
Taylor and Francis Group
Year
2007
Tongue
English
Weight
99 KB
Volume
37
Category
Article
ISSN
0039-7911

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Two new and efficient synthetic routes towards substituted 4H-1,4-benzoxazine derivatives were reported. The first one involves the synthesis in four steps of the 4-Boc-4H-1,4-benzoxazine and its regioselective substitution on C-3 following a lithiation-electrophilic substitution sequence. The secon