Regioselective and Divergent Opening of Vinyl Epoxides with Alkyne Nucleophiles
β Scribed by Per Restorp; Peter Somfai
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 120 KB
- Volume
- 2005
- Category
- Article
- ISSN
- 1434-193X
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π SIMILAR VOLUMES
## Ring opening reactions O 0132 Regioselective and Divergent Opening of Vinyl Epoxides with Ethoxyacetylene. -A divergent protocol for regioselective alkynylations of vinyl epoxides (I) and (IV) is described. The combination of lithium ethoxyacetylide (II) and BF3β’Et2O gives SN2 displacement, cf
## Abstract The use of trialkylorganozincates and tetraalkylaluminates allows regioselective S~N~2 nucleophilic opening of vinylic epoxides. The reaction occurs with an __anti__βsubstitution pattern and can be applied to a wide range of substrates. We also show that the solvent and the structure of