Regioselective and Divergent Opening of Vinyl Epoxides with Alkyne Nucleophiles.
β Scribed by Per Restorp; Peter Somfai
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 36 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The use of trialkylorganozincates and tetraalkylaluminates allows regioselective S~N~2 nucleophilic opening of vinylic epoxides. The reaction occurs with an __anti__βsubstitution pattern and can be applied to a wide range of substrates. We also show that the solvent and the structure of