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Regional measurement of the Gd-DTPA tissue partition coefficient in canine myocardium

✍ Scribed by Paul A. Harris; Christine H. Lorenz; George E. Holburn; Knowles A. Overholser

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 488 KB
Volume: 38
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910380406

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✦ Synopsis

Abstract

Quantifiable MRI perfusion studies using the contrast agent Gd‐DTPA require measurement or estimation of the tissue partition coefficient (λ) for tracer kinetic modeling. Radiotracer techniques were used to obtain regional λ measurements from the left ventricles of five dogs. Measurements were analyzed to determine whether spatial heterogeneity was a major component of λ variability. No systematic variations were identified in terms of radial position, short‐axis slice location, or wall position. The high λ variability seen in this study and in cited data of others may be due in part to tissue heterogeneity in interstitial volume, plasma volume, and perfusate hematocrit.

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## Abstract The partition coefficient of Gd‐DTPA (λ) is elevated in infarcted relative to normal myocardium. Although MRI following an infusion of Gd‐DTPA allows for the quantification of λ, infarct imaging is more routinely performed using a bolus. In this study we sought to determine how image de