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Regional distribution of high and low affinity states of dopamine D2/3 receptor binding in humans: A PET study using [11C]MNPA and [11C]raclopride

✍ Scribed by Fumitoshi Kodaka; Hiroshi Ito; Harumasa Takano; Hidehiko Takahashi; Ryosuke Arakawa; Saori Fujie; Takeshi Sasaki; Kazuhiko Nakayama; Christer Halldin; Lars Farde; Tetsuya Suhara

Book ID: 119331330
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 47 KB
Volume: 52
Category: Article
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2010.04.076

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## Abstract The D~2~ receptors exist in either the high‐ or low‐affinity state with respect to agonists, and while agonists bind preferentially to the high‐affinity state, antagonists do not distinguish between the two states. [^11^C]‐(+)‐PHNO is a PET D~2~ __agonist__ radioligand and therefore pro