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Dopamine D2/D3 receptor occupancy of apomorphine evaluated with the agonist radioligand [11C]MNPA and the antagonist radioligand [11C]Raclopride. A PET evaluation in the non-human primate brain

✍ Scribed by Sjoerd Finnema; B. Bang-Andersen; L. Farde; B. Gulyás; H.V. Wikström; C. Halldin


Book ID
118490029
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
49 KB
Volume
31
Category
Article
ISSN
1053-8119

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A two-step one-pot radiosynthesis of the
✍ C. Steiger; S. J. Finnema; L. Raus; M. Schou; R. Nakao; K. Suzuki; V. W. Pike; H 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 295 KB

## Abstract (__R__)‐(−)‐2‐[^11^C]Methoxy‐__N__‐__n__‐propylnorapomorphine ([^11^C]MNPA ([^11^C]2)) is an agonist radioligand of interest for imaging D~2~/D~3~ receptors __in vivo__. Here we sought to develop an improved radiosynthesis of this radioligand. Reference 2 was synthesized in nine steps w