Regiodivergent Ring Opening of Chiral Aziridines
β Scribed by Wu, B.; Parquette, J. R.; RajanBabu, T. V.
- Book ID
- 125509956
- Publisher
- American Association for the Advancement of Science
- Year
- 2009
- Tongue
- English
- Weight
- 109 KB
- Volume
- 326
- Category
- Article
- ISSN
- 0036-8075
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π SIMILAR VOLUMES
This account of research work on nucleophilic ring opening (NRO) of aziridines (Az's) demonstrates the broad synthetic scope of this reaction, inclusive secondary reactions, and it discusses the special mechanistic fundamentals and details as well as mechanistic variants. Formation of a C-C bond by
## Abstract **Cooperative metal centers** in a bimetallic catalyst facilitate the highly enantioselective ring opening of __meso__ aziridines **1** with silyl nucleophiles (see scheme; TMS=trimethylsilyl). The 1,2βazidoamides **2** and 1,2βamidonitriles **3** obtained in this way in high yields and