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Nucleophilic ring opening of aziridines

✍ Scribed by Helmut Stamm

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
139 KB
Volume
341
Category
Article
ISSN
1615-4150

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✦ Synopsis

This account of research work on nucleophilic ring opening (NRO) of aziridines (Az's) demonstrates the broad synthetic scope of this reaction, inclusive secondary reactions, and it discusses the special mechanistic fundamentals and details as well as mechanistic variants. Formation of a C-C bond by NRO is the red thread in this report. A central mechanistic aspect is the quality of the leaving group in Az bases, Scheme 1 Nucleophilic Ring Opening of three-membered Rings

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