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Regiocontrolled Synthesis of Substituted Thiazoles

โœ Scribed by Hodgetts, Kevin J.; Kershaw, Mark T.


Book ID
121295885
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
41 KB
Volume
4
Category
Article
ISSN
1523-7060

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Practical synthesis of fully-substituted
โœ John L. Buchanan; Ukti N. Mani; Hilary R. Plake; Dennis A. Holt ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 256 KB

The synthesis of optically active 2,4,5-substituted 1,3-thiazoles (peptide thiazoles) is described. Both the chirality and the set of side chain functionality in this fully-substituted scaffold are derived from a combination of two amino acids and one organometallic reagent. Preliminary results, wit