Practical synthesis of fully-substituted peptide thiazoles

✍ Scribed by John L. Buchanan; Ukti N. Mani; Hilary R. Plake; Dennis A. Holt

• Book ID: 104261442
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 256 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00659-0

✦ Synopsis

The synthesis of optically active 2,4,5-substituted 1,3-thiazoles (peptide thiazoles) is described. Both the chirality and the set of side chain functionality in this fully-substituted scaffold are derived from a combination of two amino acids and one organometallic reagent. Preliminary results, with two specific examples, highlight the potential of this strategy for the preparation of a diverse set of building blocks.