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Regio-Selectivity of Purified Forms of Rabbit Liver Microsomal Cytochrome P-450 in the Metabolism of Benzo(a)pyrene, n-Hexane and 7-Ethoxyresorufin

✍ Scribed by Nilsen, Odd G. ;Toftgård, Rune ;Eng, Lars ;Gustafsson, Jan-åke


Book ID
114799960
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
646 KB
Volume
48
Category
Article
ISSN
0001-6683

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## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__‐7, 8‐dihydrodiol (7, 8‐diol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino